Light: A new Masada medical thriller coming this summer

Leonard Zwelling

Dr. Zwelling is a board-certified internist and medical oncologist. He was trained at Duke University, Duke Medical School and Duke Hospital after which he completed his oncology training at the National Cancer Institute. He started his research career at NCI and in 1984 moved to The University of Texas MD Anderson Cancer Center where he rose to the rank of Professor of Medicine and Pharmacology. He returned to business school at the University of Houston, graduating in 1993. He then gravitated to research administration.

A Toxic Research Environment?

I think it was about 2003 when it began. Members of my staff housed in the oldest part of the Pink Palace (the original MD Anderson building) began having upper respiratory symptoms–coughs, mucous discharges and breathing problems. My Associate Vice President at the time was among those affected. She called in Environmental Health and Safety and after at least two if not three tries, the environmentalists determined that the duct work in our part of the building was disintegrating and the particulate matter being extruded from the ducts was making people ill.

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The CMS Aduhelm Decision: Why It Was Dead On

I adore The Wall Street Journal and often agree with its politics, but the editorial that led the Journal’s editorial page, Review & Outlook, on Monday January 24 misses the mark completely.

The Journal calls the Centers for Medicare and Medicaid Services (CMS) a “death panel” for being unwilling to pay for a new class of Alzheimer’s drug that was given accelerated approval by the FDA recently despite the advisory board’s recommendation not to do so. While it may be true that these new agents like Aduhelm decrease the amyloid in the brains of people with Alzheimer’s, they have not been conclusively shown to alter the course of the disease or the decline in cognitive function of its victims. Thus, CMS will pay for the drug IF the recipient is on a clinical trial—one that is randomized between drug and placebo. This is exactly as should be the case with a drug given accelerated approval. That approval basically says we need more data to know if this really works, but since it might and the target disease is one desperately needing treatment, a randomized, placebo-controlled trial is the best way to do it.

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The Downstream Effects Of Politics

On Saturday, January 22, two opinion pieces appeared in The New York Times that comment on the effects of politics on the health of Americans.

In the first by Cecile Richards, the former president of Planned Parenthood and daughter of Ann Richards, she notes her regret on what she believes is the eve of the end of Roe v. Wade freedom for women to control their reproductive rights. Her regret is that she underestimated the degree to which the opponents of Planned Parenthood in the Republican Party would go to overturn Roe. I feel her pain. While I respect the viewpoint of the pro-life camp, the consequences of overturning Roe are just too dire. Back-alley abortions will return and women will die for lack of access to safe pregnancy termination. I understand the need for revisiting the time frame when legal abortion should be allowed, but 6 weeks is ridiculous and the fact that the enforcement of the Texas law is supposed to be via ratting on your neighbor is absurd.

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Is The Presence Or Absence Of A Mandate The Real Issue With Covid Vaccination?

In a recent discussion with a blog reader, the question arose about the value of the vaccination mandates being forwarded by the Biden Administration and the courts’ seeming unwillingness to go along. In the course of that discussion, the polio vaccine question arose as well. In 1954, was the Salk vaccine mandated? Answer, it didn’t have to be. People couldn’t get the stuff into their kids’ arms fast enough. I still remember being taken downtown to Bridgeport, Connecticut to get my first shot. I stood in a long line with many children who were brought there by anxious parents to try to stave off the threat of a crippling disease. No one had to encourage anyone to get the shot and there were no protests that I recall. Yes, there were adverse side effects, but this predated the existence of Institutional Review Boards and detailed protocols for clinical research, not to mention the FDA’s authority over the effectiveness of vaccines. Why is it so different now?

In a word—trust.

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Is The Ukraine Less Valuable Than Kuwait?

When Saddam Hussein moved into Kuwait and declared it part of Iraq, then President George H. W. Bush moved into action. He coalesced the world against Hussein (because he uniquely could) and mobilized the United Nations to declare Hussein’s actions intolerable. Then he did one more important thing. He backed up all the talk with action and drove Hussein out of Kuwait and back into Iraq using the American military. Then, he went home.

Why isn’t the same being considered when it comes to Russia’s actions in the Ukraine?

In a word—oil. Kuwait had it. We needed it. Not so with the Ukraine. Russia is the one with the energy needed in Europe, especially in Germany.

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Why Autocracy Is A Bad Idea

Autocracy is basically a system of government under the control of a single person. China, Russia and Iran are all autocracies despite having the trappings of representative leadership, like meaningless parliaments. There is no shared governance in these places and the boss doesn’t consult with anyone when he wants to do something—like invade the Ukraine, or Taiwan, or Israel.

This poses a real problem for the United States which is anything but an autocracy. It’s supposed to be a republic (not a democracy) with representative government, an elected President, elected congresspeople and federal justices appointed by the executive and approved by the legislature. In essence running an autocracy is far more efficient than running a representative government and decisions can be made faster in the former, but it’s no way to run a government if the people’s will is to be considered in important decisions. This puts our current national leadership in a bit of a bind.

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The Djokovic Decision

As I understand the scenario, the world’s number one men’s tennis player had contracted Covid in December and recovered despite having met unmasked with young tennis players and the press when he was probably infectious. Then he traveled to Australia to play in the Open there, but was stopped at the border because he was not vaccinated. He was thrown into quarantine and his lawyers appealed in court. The initial hearing granted him entry, but then the key Australian government minister denied him access to the country again and now he is deported without being allowed to play in the tournament. If he won this tournament, he would have accrued the most Grand Slam titles of any man in history, so this is not a small matter in tennis.

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Asserting Clarity

In her op-ed in The Wall Street Journal on January 15, Peggy Noonan soundly criticizes the recent Georgia voting rights speech given by President Biden as divisive. It was followed the next day by a speech from Mitch McConnell basically agreeing with Noonan.

It has been very frustrating for me as a blogger to be accused of having progressive-liberal tendencies, when I am trying to make a case for the middle-of-the-road. Biden has just made my job easier.

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Are Voting Rights Really Being Challenged?

Based on the rhetoric emanating from the mouth of the President of the United States, one might conclude that the number of voters last election day was at an all-time low due to state regulations obstructing voters’ access to the ballot. In fact, turnout was at a record high in 2020 and Mr. Biden was the beneficiary thereof. He is claiming that new state laws will prevent that from happening again. But, is there really an emergency in the country with regard to voting rights because state legislatures are passing bills restricting mail-in ballots and Sunday voting? And by the way, is picture ID verification of identity to vote all that bad an idea anyway? And why should the doling out of food and water even be a voting issue?

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